Abstract
The synthesis and kinase inhibitory activity of a series of novel 1,7-annulated indolocarbazoles 6 and 16 is described. These compounds exhibited potent inhibitory activity against cyclin-dependent kinase 4 and good antiproliferative activity in a human colon carcinoma cell line.
MeSH terms
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Carbazoles / chemistry*
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Carbazoles / pharmacology
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Cyclin D1 / antagonists & inhibitors
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Cyclin D1 / metabolism
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Cyclin-Dependent Kinase 4
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Cyclin-Dependent Kinases / antagonists & inhibitors*
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Cyclin-Dependent Kinases / metabolism
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Indoles / chemistry*
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Indoles / pharmacology
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Protein Kinase Inhibitors / chemistry*
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Protein Kinase Inhibitors / pharmacology
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Proto-Oncogene Proteins / antagonists & inhibitors
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Proto-Oncogene Proteins / metabolism
Substances
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Carbazoles
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Indoles
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Protein Kinase Inhibitors
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Proto-Oncogene Proteins
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Cyclin D1
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Cyclin-Dependent Kinase 4
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Cyclin-Dependent Kinases